期刊
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
卷 3, 期 7, 页码 484-490出版社
J INFECTION DEVELOPING COUNTRIES
DOI: 10.3855/jidc.465
关键词
DNA adenine methylase; Pathogenesis; Salmonella enterica
资金
- Agencia Nacional de Promocion a la Ciencia y Tecnologia [PICT-2006-00407]
- Universidad de Buenos Aires (UBACyT), Argentina [M608, M009]
Dam methylation is an essential factor involved in the virulence of an increasing number of bacterial pathogens including Salmonella enterica. Lack of Dam methylation causes severe attenuation in animal models. It has been proposed that dysregulation of Dam activity is potentially a general strategy for the generation of vaccines against bacterial pathogens. In this review, we focus our attention on the role of methylation by Dam protein in regulating bacterial gene expression and virulence in Salmonella enterica.
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