期刊
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
卷 22, 期 4, 页码 359-373出版社
ELSEVIER
DOI: 10.1016/j.sjbs.2014.10.002
关键词
BRAF gene; RAS-RAF overactivation; Cancers; Developmental syndromes
类别
The BRAF gene encodes for a serine/threonine protein kinase that participates in the MAPK/ERK signalling pathway and plays a vital role in cancers and developmental syndromes (RASopathies). The current review discusses the clinical significance of the BRAF gene and other members of RAS/RAF cascade in human cancers and RAS/MAPK syndromes, and focuses the molecular basis and clinical genetics of BRAF to better understand its parallel involvement in both tumourigenesis and RAS/MAPK syndromes--Noonan syndrome, cardio-facio-cutaneous syndrome and LEOPARD syndrome. (C) 2014 Production and hosting by Elsevier B.V. on behalf of King Saud University.
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