期刊
JOURNAL OF FORENSIC AND LEGAL MEDICINE
卷 27, 期 -, 页码 17-24出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jflm.2014.07.008
关键词
Gamma-hydroxybutyric acid (GHB); Endogenous and post-mortem behaviour; Cut-off reference values; Sample collection; Storage conditions; Forensic toxicology
Gamma-Hydroxybutyric Acid (GHB) is an endogenous compound with a story of clinical use, since the 1960's. However, due to its secondary effects, it has become a controlled substance, entering the illicit market for recreational and dance club scene use, muscle enhancement purposes and drug-facilitated sexual assaults. Its endogenous context can bring some difficulties when interpreting, in a forensic context, the analytical values achieved in biological samples. This manuscript reviewed several crucial aspects related to GHB forensic toxicology evaluation, such as its post-mortem behaviour in biological samples; endogenous production values, whether in in vivo and in post-mortem samples; sampling and storage conditions (including stability tests); and cut-off reference values evaluation for different biological samples, such as whole blood, plasma, serum, urine, saliva, bile, vitreous humour and hair. This revision highlights the need of specific sampling care, storage conditions, and cut-off reference values interpretation in different biological samples, essential for proper practical application in forensic toxicology. (C) 2014 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.
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