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Intracerebroventricular Leptin Infusion Improves Glucose Homeostasis in Lean Type 2 Diabetic MKR Mice via Hepatic Vagal and Non-Vagal Mechanisms
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Central leptin action improves skeletal muscle AKT, AMPK, and PGC1α activation by hypothalamic PI3K-dependent mechanism
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Central infusion of leptin improves insulin resistance and suppresses β-cell function, but not β-cell mass, primarily through the sympathetic nervous system in a type 2 diabetic rat model
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Leptin therapy in insulin-deficient type I diabetes
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Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice
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An Osteoblast-dependent Mechanism Contributes to the Leptin Regulation of Insulin Secretion
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Chronic leptin treatment stimulates lipid oxidation in immortalized and primary mouse skeletal muscle cells
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PET Imaging of Leptin Biodistribution and Metabolism in Rodents and Primates
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Distinct Effects of Leptin and a Melanocortin Receptor Agonist Injected Into Medial Hypothalamic Nuclei on Glucose Uptake in Peripheral Tissues
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DIABETES (2009)
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DIABETES (2009)
A Functional Melanocortin System May Be Required for Chronic CNS-Mediated Antidiabetic and Cardiovascular Actions of Leptin
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DIABETES (2009)
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Chronic central leptin infusion restores cardiac sympathetic-vagal balance and baroreflex sensitivity in diabetic rats
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ENDOCRINOLOGY (2008)
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MOLECULAR THERAPY (2008)
Leptin Replacement Improves Cognitive Development
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PLOS ONE (2008)
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Leptin deficiency Per se dictates body composition and insulin action in ob/ob mice
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Disruption of leptin receptor expression in the pancreas directly affects β cell growth and function in mice
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JOURNAL OF CLINICAL INVESTIGATION (2007)
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JOURNAL OF APPLIED PHYSIOLOGY (2007)
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Leptin transgene expression in the hypothalamus enforces euglycemia in diabetic, insulin-deficient nonobese Akita mice and leptin-deficient obese ob/ob mice
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PEPTIDES (2006)
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JOURNAL OF MOLECULAR ENDOCRINOLOGY (2006)
Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight
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JOURNAL OF CLINICAL INVESTIGATION (2005)
Inhibition of preproinsulin gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic β-cells
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Central leptin acutely reverses diet-induced hepatic insulin resistance
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DIABETES (2005)
Sensitivity of ob/ob mice to leptin-induced adipose tissue apoptosis
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OBESITY RESEARCH (2005)
Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression - I. Pathophysiological analysis
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Leptin reduces glucose transport and cellular ATP levels in INS-1 β-cells
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J Licinio et al.
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Leptin impairs insulin signaling in rat adipocytes
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Congenital leptin deficiency due to homozygosity for the Δ133G mutation:: Report of another case and evaluation of response to four years of leptin therapy
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Regulation of hepatic glucose metabolism by leptin in pig and rat primary hepatocyte cultures
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Adipocyte-selective reduction of the leptin receptors induced by antisense RNA leads to increased adiposity, dyslipidemia, and insulin resistance
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Leptin as an adjunct of insulin therapy in insulin-deficient diabetes
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STAT3 signalling is required for leptin regulation of energy balance but not reproduction
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NATURE (2003)
Leptin constrains phospholipase C-protein kinase C-induced insulin secretion via a phosphatidylinositol 3-kinase-dependent pathway
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AMP kinase activation ameliorates insulin resistance induced by free fatty acids in rat skeletal muscle
GS Olsen et al.
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Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones.
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Leptin accelerates autoimmune diabetes in female NOD mice
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Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats
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MOLECULAR ENDOCRINOLOGY (2002)
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HORMONE AND METABOLIC RESEARCH (2002)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
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JOURNAL OF CLINICAL INVESTIGATION (2001)
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DIABETES (2001)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Selective interaction between leptin and insulin signaling pathways in a hepatic cell line
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)