Retinaldehyde/hyaluronic acid fragments: a synergistic association for the management of skin aging

Background Retinaldehyde (RAL) was proven effective in treating photodamaged skin. Topical treatments with specific intermediate-size hyaluronate fragments (HAFi, 50-400 kDa) have been shown to stimulate keratinocytes proliferation and epidermal hyperplasia. The aim of this open, multicentric, international study was to assess the efficacy of the combination RAL-HAFi in the correction of skin photoaging. Patients/Methods Either RAL 0.05%-HAFi 0.5% (Eluage (R) cream; group 1) or RAL 0.05%-HAFi 1% (Eluage (R) antiwrinkle concentrate; group 2) or both products (group 3) were applied daily to the 1462 subjects during 90 days. Overall photoaging severity was evaluated in the three groups by the dermatologists at D0, D30, and D90 based on the Larnier's scale. Wrinkles and/or furrows and clinical signs of aging were evaluated using a 4-point scale. The skin microrelief of the crow's feet, evaluated by optical profilometry, was performed in subjects from group 3. Results The 3-month application significantly improved overall photoaging through decrease of the Larnier's score in the three groups (P < 0.001). At D90, significant improvement of wrinkles was shown in groups 2 and 3 [forehead wrinkles (-19% and -10%, respectively, P < 0.001), nasolabial folds (-20% and -16%, P < 0.001), crow's feet (-27% in the two groups, P < 0.001), and perioral wrinkles (-34% and -23%, P < 0.001)]. Clinical signs of photoaging on the entire face improved significantly in groups 1 and 3 [elasticity (-32% and -33%, respectively, P < 0.001), hyperpigmentation (-34% and -31%, P < 0.001), and ptosis (-18% and -22%; P < 0.001)]. Results were confirmed using an optical profilometry technique. Products were very well tolerated. Conclusion This clinical study showed the efficacy and value of the RAL-HAFi combination in the management of aging skin in a large cohort of patients.