期刊
ISLETS
卷 2, 期 4, 页码 247-251出版社
LANDES BIOSCIENCE
DOI: 10.4161/isl.2.4.12402
关键词
fibroblast growth factor-21; diabetes mellitus; islet transplantation; beta-cell load; insulin sensitivity; cytoprotection; apoptosis
资金
- Ministry of Health, Labour and Welfare of Japan
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Kyoto University
To clarify the effect of fibroblast growth factor-21 (FGF-21) on islet transplantation, a suboptimal number of islets were transplanted into streptozotocin (STZ)-induced diabetic mice with or without FGF-21 treatment. Three-day treatment with FGF-21 contributed to restoration of normoglycemia by suppressing islet graft loss. The FGF-21-treated mice showed lower glycemic levels despite similar insulin content in the graft than that in untreated mice on day 3, indicating that FGF-21 not only has a cytoprotective effect but also decreases beta-cell load by increasing insulin sensitivity. These results suggest that FGF-21 may be useful as a treatment to improve islet engraftment rates in clinical islet transplantation.
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