期刊
PATHOGENS AND DISEASE
卷 73, 期 8, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/femspd/ftv060
关键词
antiplatelets; prophylaxis; experimental endocarditis; Enterococcus faecalis; Streptococcus gallolyticus
资金
- Swiss National Science Foundation [310030-125325, 310030-143799/1]
- Swiss National Science Foundation (SNF) [310030_125325, 310030_143799] Funding Source: Swiss National Science Foundation (SNF)
Enterococcus faecalis and Streptococcus gallolyticus cause infective endocarditis (IE), which can originate from the continuous release or translocation of low bacterial numbers into the bloodstream. In this context, IE cannot be prevented with antibiotics. We previously demonstrated that aspirin plus ticlopidine protected rats from IE due to S. gordonii and Staphylococcus aureus. Here we showed that aspirin plus ticlopidine significantly reduced vegetation weight and protected 73 and 64% rats (P < 0.005) from IE due to E. faecalis and S. gallolyticus, respectively. These results further support the potential use of aspirin plus ticlopidine for a global prevention of IE in high-risk patients.
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