Insights into the potential use of microRNAs as biomarker in cancer

MicroRNAs (miRs) are small non-coding RNAs, which regulate gene expression profiles of several genes. Consequently, miRs control and regulate several vital cellular processes like proliferation, apoptosis, differentiation, etc. Not surprisingly, altered expression of miRs has been linked to cancer development and progression. Recent studies have shown that sufficiently stable miRs can be isolated from the serum and other body fluids of cancer patients. The distinct miR profiles in the cell free circulating fluids of cancer patients have a potential to become a new class of biomarkers to detect and prognosticate cancers. In this review, we first briefly address the biogenesis of miRs and their role in gene regulation. Subsequently, we highlighted the role of miRs in pathogenesis of diseases with an emphasis on cancers. Finally, since, miRs have been shown to be promising circulating biomarkers for cancer detection, we 1) summarize the work done to date and 2) highlight the most significant advances resulting from these studies. (C) 2012 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.