期刊
NANOSCALE RESEARCH LETTERS
卷 10, 期 -, 页码 -出版社
SPRINGER
DOI: 10.1186/s11671-015-0768-8
关键词
Zeolite; Clinoptilolite; Zeolite BEA; Zeolite A; Enzyme; Biosensor; pH-ISFET
资金
- Project European IRSES-NANODEV
- National Academy of Sciences of Ukraine
A number of potentiometric biosensors based on coimmobilization of enzymes with different types of zeolite on pH-ion-sensitive field-effect transistor (ISFET) have been developed. Their working characteristics have been determined and compared. It was shown that clinoptilolite and zeolite Beta polymorph A (BEA) are more promising for creating biosensors than zeolite A. Changing the concentration of zeolite BEA in membranes, it is possible to extend the biosensor linear measurement range. The two-layer method of deposition of the enzyme with clinoptilolite was found to provide a significant increase in the biosensor sensitivity to substrates, whereas thermal modification of the zeolite BEA crystals can improve analytical characteristics of potentiometric biosensors for detection of toxic substances. These results show that it is possible to regulate the ISFET characteristics for different enzyme-based biosensors by tailoring the electrode surfaces via different zeolites. This makes zeolites strong candidates for integration into biosensors as ISFET modifiers.
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