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Ariadna Recasens et al.
ANNALS OF NEUROLOGY (2014)
BAX channel activity mediates lysosomal disruption linked to Parkinson disease
Jordi Bove et al.
AUTOPHAGY (2014)
α-Synuclein oligomers distinctively permeabilize complex model membranes
Anja N. D. Stefanovic et al.
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Jose Bras et al.
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Cristina Guardia-Laguarta et al.
JOURNAL OF NEUROSCIENCE (2014)
A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology
Petra Pasanen et al.
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G51D α-Synuclein mutation causes a novel Parkinsonian-pyramidal syndrome
Suzanne Lesage et al.
ANNALS OF NEUROLOGY (2013)
Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration
Maria Xilouri et al.
BRAIN (2013)
Alpha-synuclein and protein degradation pathways in Parkinson's disease: A pathological feed-back loop
Marta Martinez-Vicente et al.
EXPERIMENTAL NEUROLOGY (2013)
Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease
Silke Appel-Cresswell et al.
MOVEMENT DISORDERS (2013)
Emerging regulation and functions of autophagy
Patricia Boya et al.
NATURE CELL BIOLOGY (2013)
Interplay of LRRK2 with chaperone-mediated autophagy
Samantha J. Orenstein et al.
NATURE NEUROSCIENCE (2013)
Signals from the lysosome: a control centre for cellular clearance and energy metabolism
Carmine Settembre et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
100 years of Lewy pathology
Michel Goedert et al.
NATURE REVIEWS NEUROLOGY (2013)
The many faces of alpha-synuclein: from structure and toxicity to therapeutic target
Hilal A. Lashuel et al.
NATURE REVIEWS NEUROSCIENCE (2013)
A NOVEL α-SYNUCLEIN MISSENSE MUTATION IN PARKINSON DISEASE
Christos Proukakis et al.
NEUROLOGY (2013)
Alpha-Synuclein Induces Lysosomal Rupture and Cathepsin Dependent Reactive Oxygen Species Following Endocytosis
David Freeman et al.
PLOS ONE (2013)
TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity
Mickael Decressac et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
An ERcentric view of Parkinson's disease
Gabriela Mercado et al.
TRENDS IN MOLECULAR MEDICINE (2013)
Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein
Nunilo Cremades et al.
CELL (2012)
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
Carmine Settembre et al.
EMBO JOURNAL (2012)
Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration
Benjamin Dehay et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
Kelvin C. Luk et al.
SCIENCE (2012)
Lysosomal membrane permeabilization in Parkinson disease
Miquel Vila et al.
AUTOPHAGY (2011)
Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies
Joseph R. Mazzulli et al.
CELL (2011)
Lysosomal Ca2+ homeostasis: Role in pathogenesis of lysosomal storage diseases
Emyr Lloyd-Evans et al.
CELL CALCIUM (2011)
DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy
Kelly Jean Thomas et al.
HUMAN MOLECULAR GENETICS (2011)
α-Synuclein at the Mitochondrial Membrane: Prelude to a Kill♦
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Sumoylation inhibits α-synuclein aggregation and toxicity
Petranka Krumova et al.
JOURNAL OF CELL BIOLOGY (2011)
α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
Christian Hansen et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies
Michael A. Nalls et al.
LANCET (2011)
α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
Tim Bartels et al.
NATURE (2011)
The elimination of accumulated and aggregated proteins: A role for aggrephagy in neurodegeneration
Ai Yamamoto et al.
NEUROBIOLOGY OF DISEASE (2011)
Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
Lydia Alvarez-Erviti et al.
NEUROBIOLOGY OF DISEASE (2011)
WHAT GENETICS TELLS US ABOUT THE CAUSES AND MECHANISMS OF PARKINSON'S DISEASE
Olga Corti et al.
PHYSIOLOGICAL REVIEWS (2011)
In vivo demonstration that α-synuclein oligomers are toxic
Beate Winner et al.
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Glucocerebrosidase is present in α-synuclein inclusions in Lewy body disorders
Ozlem Goker-Alpan et al.
ACTA NEUROPATHOLOGICA (2010)
Genome-Wide Association Study Confirms SNPs in SNCA and the MAPT Region as Common Risk Factors for Parkinson Disease
Todd L. Edwards et al.
ANNALS OF HUMAN GENETICS (2010)
alpha-Synuclein: Membrane Interactions and Toxicity in Parkinson's Disease
Pavan K. Auluck et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 26 (2010)
Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains
Lydia Alvarez-Erviti et al.
ARCHIVES OF NEUROLOGY (2010)
Lysosomal membrane proteins: life between acid and neutral conditions
Paul Saftig et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2010)
Lysosomal Degradation of α-Synuclein in Vivo
Sally K. Mak et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Rapamycin Protects against Neuron Death in In Vitro and In Vivo Models of Parkinson's Disease
Cristina Malagelada et al.
JOURNAL OF NEUROSCIENCE (2010)
Pathogenic Lysosomal Depletion in Parkinson's Disease
Benjamin Dehay et al.
JOURNAL OF NEUROSCIENCE (2010)
Cell-Produced α-Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival
Evangelia Emmanouilidou et al.
JOURNAL OF NEUROSCIENCE (2010)
The Selective Macroautophagic Degradation of Aggregated Proteins Requires the PI3P-Binding Protein Alfy
Maria Filimonenko et al.
MOLECULAR CELL (2010)
Autophagy gone awry in neurodegenerative diseases
Esther Wong et al.
NATURE NEUROSCIENCE (2010)
DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function
Ling-Yang Hao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Molecular and cellular basis of lysosomal transmembrane protein dysfunction
Raquel Ruivo et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2009)
Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in α-Synuclein Models of Parkinson's and Lewy Body Diseases
Brian Spencer et al.
JOURNAL OF NEUROSCIENCE (2009)
Genome-wide association study reveals genetic risk underlying Parkinson's disease
Javier Simon-Sanchez et al.
NATURE GENETICS (2009)
Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions
Yaping Chu et al.
NEUROBIOLOGY OF DISEASE (2009)
Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease
E. Sidransky et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
A Swedish family with de novo α-synuclein A53T mutation: Evidence for early cortical dysfunction
Andreas Puschmann et al.
PARKINSONISM & RELATED DISORDERS (2009)
Regulation of Neuronal Survival Factor MEF2D by Chaperone-Mediated Autophagy
Qian Yang et al.
SCIENCE (2009)
Aberrant molecular properties shared by familial Parkinson's disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1
Tomohiro Kabuta et al.
HUMAN MOLECULAR GENETICS (2008)
Dopamine-modified α-synuclein blocks chaperone-mediated autophagy
Marta Martinez-Vicente et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Analysis of PARK genes in a Korean cohort of early-onset Parkinson disease
Jung Mi Choi et al.
NEUROGENETICS (2008)
Lysosomal membrane permeabilization in cell death
P. Boya et al.
ONCOGENE (2008)
The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis
Aaron D. Gitler et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Integral and associated lysosomal membrane proteins
Bernd Schroeder et al.
TRAFFIC (2007)
Lysosomes: fusion and function
J. Paul Luzio et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
ATP13A2 missense mutations in juvenile parkinsonism and young onset Parkinson disease
A. Di Fonzo et al.
NEUROLOGY (2007)
The Ala53Thr mutation in the α-synuclein gene in a Korean family with Parkinson disease
C-S Ki et al.
CLINICAL GENETICS (2007)
Phosphorylation of Ser-129 is the dominant pathological modification of α-synuclein in familial and sporadic Lewy body disease
John P. Anderson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase
Alfredo Ramirez et al.
NATURE GENETICS (2006)
α-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
Antony A. Cooper et al.
SCIENCE (2006)
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
A Bender et al.
NATURE GENETICS (2006)
Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and α-synuclein
V Dorval et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Ageing and neuronal vulnerability
MP Mattson et al.
NATURE REVIEWS NEUROSCIENCE (2006)
Parkinson's disease α-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death
LJ Martin et al.
JOURNAL OF NEUROSCIENCE (2006)
Lysosomal membrane permeabilization during apoptosis -: involvement of Bax?
K Kågedal et al.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (2005)
Intravesicular localization and exocytosis of α-synuclein and its aggregates
HJ Lee et al.
JOURNAL OF NEUROSCIENCE (2005)
The new mutation, E46K, of α-synuclein causes Parkinson and Lewy body dementia
JJ Zarranz et al.
ANNALS OF NEUROLOGY (2004)
α-synuclein locus duplication as a cause of familial Parkinson's disease
MC Chartier-Harlin et al.
LANCET (2004)
Impaired degradation of mutant α-synuclein by chaperone-mediated autophagy
AM Cuervo et al.
SCIENCE (2004)
Understanding aging: revealing order out of chaos
E Dufour et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2004)
Mutations in the glucocerebrosidase gene and Parkinson's disease in Ashkenazi Jews
J Aharon-Peretz et al.
NEW ENGLAND JOURNAL OF MEDICINE (2004)
Ubiquitination of α-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function
GK Tofaris et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
α-synuclein locus triplication causes Parkinson's disease
AB Singleton et al.
SCIENCE (2003)
Effects of oxidative and nitrative challenges on α-synuclein fibrillogenesis involve distinct mechanisms of protein modifications
EH Norris et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
α-synuclein is degraded by both autophagy and the proteasome
JL Webb et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Nitration inhibits fibrillation of human α-synuclein in vitro by formation of soluble oligomers
G Yamin et al.
FEBS LETTERS (2003)
α-Synuclein is phosphorylated in synucleinopathy lesions
H Fujiwara et al.
NATURE CELL BIOLOGY (2002)
Clinical and pathological features of a parkinsonian syndrome in a family with an Ala53Thr α-synuclein mutation
PJ Spira et al.
ANNALS OF NEUROLOGY (2001)
Oxidative damage linked to neurodegeneration by selective α-synuclein nitration in synucleinopathy lesions
BI Giasson et al.
SCIENCE (2000)
Characterisation of isolated α-synuclein filaments from substantia nigra of Parkinson's disease brain
RA Crowther et al.
NEUROSCIENCE LETTERS (2000)
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
A Abeliovich et al.
NEURON (2000)