Dibenzoylmethane (DBM), a beta-diketone structural analogue of curcumin, has been reported to exhibit anti-tumorigenic and chemopreventive activities. Due to the structural resemblance of DBM to the anti-inflammatory curcumin and an aspirin-like skeleton of DBM derivatives, we tested the anti-inflammatory effects of DBM and its derivatives, 1,3-bis-(2-substituted-phenyl)-propane-1,3-dione, on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumor promotion as well as TPA- and arachidonic acid-induced mouse ear edema in skin of CD-1 mice. Topical application of 10 mu mol DBM together with TPA on the back of mice previously treated with 7,12-dimethylbenz[alpha]anthracene (DMBA) inhibited TPA-induced skin tumor promotion significantly. In addition, 1,3-bis-(2-acetoxy phenyl)-propane-1,3-dione was a superior anti-inflammatory agent to aspirin (80% of inhibition), on TPA-induced mouse ear edema and reduced the production of prostaglandin E2 (PGE(2)), comparable to aspirin. Taken together, 1,3-bis-(2-acetoxyphenyl-propane-1,3-dione merits a valuable anti-inflammatory agent substituting aspirin in therapeutic treatment as well prevention of cancer.
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