期刊
MICROMACHINES
卷 6, 期 12, 页码 1903-1913出版社
MDPI AG
DOI: 10.3390/mi6121464
关键词
microstructure fabrication; polymers; spatial light modulators; cell chains
类别
资金
- National Natural Science Foundation of China [61302003, 61475183, 61503258]
- CAS/SAFEA International Partnership Program for Creative Research Teams
- Instrument Developing Project of Chinese Academy of Sciences [yz201339]
Fabrication of hydrogel microstructures has attracted considerable attention. A large number of applications, such as fabricating tissue engineering scaffolds, delivering drugs to diseased tissue, and constructing extracellular matrix for studying cell behaviors, have been introduced. In this article, an ultraviolet (UV)-curing method based on a digital micromirror device (DMD) for fabricating poly(ethylene glycol) diacrylate (PEGDA) hydrogel microstructures was presented. By controlling UV projection in real-time using a DMD as digital dynamic mask instead of a physical mask, polymerization of the pre-polymer solution could be controlled to create custom-designed hydrogel microstructures. Arbitrary microstructures could also be fabricated within several seconds (<5 s) using a single-exposure, providing a much higher efficiency than existing methods, while also offering a high degree of flexibility and repeatability. Moreover, different cell chains, which can be used for straightforwardly and effectively studying the cell interaction, were formed by fabricated PEGDA microstructures.
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