期刊
DRUG DESIGN DEVELOPMENT AND THERAPY
卷 7, 期 -, 页码 1157-1178出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/DDDT.S49763
关键词
metal binding compound; antineurodegenerative; anticancer; antidiabetic; multi-functional actions; structure-activity relationships
资金
- Office of the Higher Education Commission, Mahidol University, under the National Research Universities Initiative
- Annual Governmental Grant of Mahidol University [2556-2558 BE]
Metal ions play an important role in biological processes and in metal homeostasis. Metal imbalance is the leading cause for many neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 8-Hydroxyquinoline (8HQ) is a small planar molecule with a lipophilic effect and a metal chelating ability. As a result, 8HQ and its derivatives hold medicinal properties such as antineurodegenerative, anticancer, antioxidant, antimicrobial, anti-inflammatory, and antidiabetic activities. Herein, diverse bioactivities of 8HQ and newly synthesized 8HQ-based compounds are discussed together with their mechanisms of actions and structure-activity relationships.
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