期刊
CURRENT PSYCHIATRY REPORTS
卷 15, 期 6, 页码 -出版社
SPRINGER
DOI: 10.1007/s11920-013-0360-9
关键词
Geriatric; Psychiatry; Neuroimaging; Biomarkers; Dementia; Alzheimer's disease (AD); Late-life depression (LLD); MRI; DTI; fMRI; PET; FDG-PET; Pittsburgh Compound B (PiB); White matter lesions (WML); Resting-state network; Vascular hypothesis
类别
资金
- NCATS NIH HHS [UL1 TR000005] Funding Source: Medline
- NIA NIH HHS [P30 AG024827] Funding Source: Medline
- NIMH NIH HHS [R01 MH076079] Funding Source: Medline
Neuroimaging, both structural and functional, serve as useful adjuncts to clinical assessment, and can provide objective, reliable means of assessing disease presence and process in the aging population. In the following review we briefly explain current imaging methodologies. Then, we analyze recent developments in developing neuroimaging biomarkers for two highly prevalent disorders in the elderly population- Alzheimer's disease (AD) and late-life depression (LLD). In AD, efforts are focused on early diagnosis through in vivo visualization of disease pathophysiology. In LLD, recent imaging evidence supports the role of white matter ischemic changes in the pathogenesis of depression in the elderly, the vascular hypothesis. Finally, we discuss potential roles for neuroimaging biomarkers in geriatric psychiatry in the future.
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