期刊
CURRENT OPINION IN HIV AND AIDS
卷 5, 期 4, 页码 277-282出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/COH.0b013e32833a0d3a
关键词
acute HIV infection; HIV transmission; mathematical models
资金
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIAID) [R01 AI083059]
- NIAID [T32AI070114-01]
Purpose of review Acute HIV infection (AHI), the earliest period after HIV acquisition, is only a few weeks in duration. In this brief period, the concentration of HIV in blood and genital secretions is extremely high, increasing the probability of HIV transmission. Although a substantial role of AHI in the sexual transmission of HIV is biologically plausible, the significance of AHI in the epidemiological spread of HIV remains uncertain. Recent findings AHI is diagnosed by detecting viral RNA or antigen in the blood of persons who are HIV seronegative. Depending on the setting, persons with AHI represent between 1 and 10% of persons with newly diagnosed HIV infection. The high concentration of virus during AHI leads to increased infectiousness, possibly as much as 26 times greater than during chronic infection. In mathematical models, the estimated proportion of transmission attributed to AHI has varied considerably, depending on model structure, model parameters, and the population. Key determinants include the stage of the HIV epidemic and the sexual risk profile of the population. Summary Despite its brief duration, AHI plays a disproportionate role in the sexual transmission of HIV infection. Detection of persons with AHI may provide an important opportunity for transmission prevention.
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