期刊
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
卷 35, 期 5, 页码 358-363出版社
ELSEVIER MASSON, CORPORATION OFFICE
DOI: 10.1016/j.clinre.2011.01.011
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资金
- Swiss National Science Foundation [314730-130498]
- Swiss National Science Foundation (SNF) [314730_130498] Funding Source: Swiss National Science Foundation (SNF)
The hepatitis C virus (HCV) infection has been shown to have direct and/or indirect effects on glucose metabolism, leading to insulin resistance and, in predisposed individuals, type 2 diabetes. This is supported by several experimental, clinical and epidemiological data. The detailed molecular events leading to insulin resistance in HCV-infected patients are unclear. HCV infects primarily the liver and, to a very minor extent, mononuclear cells. Direct interactions between HCV products and the hepatocyte insulin signaling pathway have been reported by several authors. However, recent evidence supports the existence of a significant extrahepatic component of HCV-induced insulin resistance. Thus, the molecular pathogenesis of glucose metabolism disturbances observed in hepatitis C is much more complex than expected. The clinical management of such condition remains empirical. (C) 2011 Elsevier Masson SAS. All rights reserved.
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