期刊
CELL MOTILITY AND THE CYTOSKELETON
卷 66, 期 5, 页码 237-247出版社
WILEY-LISS
DOI: 10.1002/cm.20357
关键词
aquaporins; cell motility; polarity; morphology; filopodia
类别
资金
- Wenner-Gren Foundation
- The Swedish Research Council (Medicine)
- The Swedish Society of Medicine
- The Magnus Bergvall Foundation
- The Clas Groschinsky Memorial Foundation
- The Faculty of Health Sciences
- Linkoping University
Transmembrane water fluxes through aquaporins (AQPs) are suggested to play, pivotal roles in cell polarization and directional cell motility. Local dilution by W water influences the dynamics of the subcortical actin polymerization and directs the formation of nascent membrane protrusions. In this paper. recent evidence is discussed in support of such a central role of AQP in membrane protrusion formation, and cell migration as a basis for our Understanding AQP9 Underlying molecular mechanisms of directional motility. Specifically. AQP9 in a physiological context controls transmembrane water fluxes driving, membrane protrusion formation, as an initial cellular response to a chemoattractant or other migratory signals. The importance of AQP-facilitated water fluxes in directional cell motility is underscored the observation that blocking or modifying specific sites in AQP9 also interferes with the molecular machinery that govern actin-mediated cellular shape changes. Cell Motil. Cytoskeleton 66: 237-247, 2009. (C) 2009 Wiley-Liss, Inc.
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