期刊
CELL MOTILITY AND THE CYTOSKELETON
卷 66, 期 12, 页码 1048-1056出版社
WILEY-LISS
DOI: 10.1002/cm.20407
关键词
profilin-1; R-cadherin; MDA-MB-231; adherens junction; cell-cell adhesion
类别
资金
- National Cancer Institute [R01-CA108607]
- NATIONAL CANCER INSTITUTE [R01CA136854, R01CA108607] Funding Source: NIH RePORTER
Profilin-1 (Pfn1), a ubiquitously expressed actin-binding protein, is downregulated in several different types of adenocarcinoma and elicits tumor-suppressive effect on breast cancer cell lines. MDA-MB-231 (MDA-231), a breast cancer cell line that displays all the characteristics of post-epithelial-to-mesenchymal transition and does not form cell-cell adhesion, can be reverted to an epithelioid phenotype by Pfn1 overexpression. This morphological transition is caused by restoration of adherens junctions (AJ) requiring Pfn1's interaction with actin. Pfn1 overexpression increases the expression level of R-cadherin (a type of cadherin that is endogenously expressed in the parental cell line) and restores AJ in MDA-231 cells in R-cadherin-dependent manner. These findings highlight important role of Pfn1 in the regulation of epithelial cell-cell adhesion. Cell Motil. Cytoskeleton 66: 1048-1056, 2009. (C) 2009 Wiley-Liss, Inc.
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