期刊
CELL MOTILITY AND THE CYTOSKELETON
卷 66, 期 8, 页码 425-436出版社
WILEY-LISS
DOI: 10.1002/cm.20313
关键词
axoneme; cilia; dynein; metachronism; motility; synchronization
类别
Bending of cilia and flagella results from sliding between the microtubular Outer doublets, driven by dynein motor enzymes. This review reminds us that many questions remain to be answered before we can understand how dynein-driven sliding causes the oscillatory bending of cilia and flagella. Does oscillation require switching between two distinct, persistent modes of dynein activity? Only one mode, an active forward mode, has been characterized, but an alternative mode, either inactive or reverse, appears to be required. Does switching between modes use information from curvature, sliding direction, or both? Is there a mechanism for reciprocal inhibition? Can a localized capability for oscillatory sliding become self-organized to produce the metachronal phase differences required for bend propagation? Are interactions between adjacent dyneins important for regulation of oscillation and bend propagation? Cell Mold. Cytoskeleton 66: 425-436, 2009. (C) 2008 Wiley-Liss, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据