期刊
CELL ADHESION & MIGRATION
卷 9, 期 1-2, 页码 48-82出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/19336918.2014.987587
关键词
biosynthesis; cancer; development; glycosylation; matrix assembly; proteolytic cleavage; splicing; tenascin-C; therapeutics; transcription
类别
资金
- Kennedy Trust for Rheumatology Research
- Arthritis Research UK
- Versus Arthritis [20003] Funding Source: researchfish
Tenascin-C is a large, multimodular, extracellular matrix glycoprotein that exhibits a very restricted pattern of expression but an enormously diverse range of functions. Here, we discuss the importance of deciphering the expression pattern of, and effects mediated by, different forms of this molecule in order to fully understand tenascin-C biology. We focus on both post transcriptional and post translational events such as splicing, glycosylation, assembly into a 3D matrix and proteolytic cleavage, highlighting how these modifications are key to defining tenascin-C function.
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