期刊
CELL ADHESION & MIGRATION
卷 7, 期 3, 页码 293-296出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.24804
关键词
focal adhesions; cell migration; mechanosensing; high-throughput phenotyping; systems biology
类别
资金
- NCI NIH HHS [R01 CA085839, CA85839, U54 CA143868, CA143868] Funding Source: Medline
- NIGMS NIH HHS [R01 GM084204, GM084204] Funding Source: Medline
Efficient cell migration is central to the normal development of tissues and organs and is involved in a wide range of human diseases, including cancer metastasis, immune responses, and cardiovascular disorders. Mesenchymal migration is modulated by focal-adhesion proteins, which organize into large integrin-rich protein complexes at the basal surface of adherent cells. Whether the extent of clustering of focal-adhesion proteins is actually required for effective migration is unclear. We recently demonstrated that the depletion of major focal-adhesion proteins, as well as modulation of matrix compliance, actin assembly, mitochondrial activity, and DNA recombination, all converged into highly predictable, inter-related, biphasic changes in focal adhesion size and cell migration. Herein, we further discuss the role of focal adhesions in controlling cell spreading and test their potential role in cell migration.
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