期刊
CELL ADHESION & MIGRATION
卷 7, 期 5, 页码 418-423出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.26375
关键词
PTP1B; integrins; adhesions; migration; endoplasmic reticulum; alpha-actinin; Src; cytoskeleton
类别
资金
- Agencia Nacional para la Promocion Cientifica y Tecnologica (ANPCYT)
- Consejo Nacional de Investigaciones Cientificas y Tecnologicas (CONICET)
- ANPCYT [PICTs 1363, 2129]
Cell migration requires a highly coordinated interplay between specialized plasma membrane adhesion complexes and the cytoskeleton. Protein phosphorylation/dephosphorylation modifications regulate many aspects of the integrin-cytoskeleton interdependence, including their coupling, dynamics, and organization to support cell movement. The endoplasmic reticulum-bound protein tyrosine phosphatase PTP1B has been implicated as a regulator of cell adhesion and migration. Recent results from our laboratory shed light on potential mechanisms, such as Src/FAK signaling through Rho GTPases and integrin-cytoskeletal coupling.
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