期刊
CELL ADHESION & MIGRATION
卷 7, 期 1, 页码 101-110出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.22680
关键词
basement membrane; laminin; endothelium; vascular smooth muscle; blood vessels
类别
资金
- German Research Foundation [DFG SFB 293A19, SO285/9-1]
- FP-7 People Programme (Marie Curie Actions) under REA grant [235711 (SmArt)]
Laminins, one of the major functional components of basement membranes, are found underlying endothelium, and encasing pericytes and smooth muscle cells in the vessel wall. Depending on the type of blood vessel (capillary, venule, postcapillary venule, vein or artery) and their maturation state, both the endothelial and mural cell phenotype vary, with associated changes in laminin isoform expression. Laminins containing the alpha 4 and alpha 5 chains are the major isoforms found in the vessel wall, with the added contribution of laminin alpha 2 in larger vessels. We here summarize current data on the precise localization of these laminin isoforms and their receptors in the different layers of the vessel wall, and their potential contribution to vascular homeostasis.
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