期刊
CELL ADHESION & MIGRATION
卷 6, 期 5, 页码 397-403出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.21103
关键词
cell migration; adhesion; mesoderm spreading; caudal visceral mesoderm; FGF signaling; Heartless; Pyramus; Thisbe; Drosophila embryo
类别
资金
- American Heart Association
- Moore Foundation CISR.CACR Bio-Grant
- March of Dimes [1-FY11-423]
Cell migration influences cell-cell interactions to drive cell differentiation and organogenesis. To support proper development, cell migration must be regulated both temporally and spatially. Mesoderm cell migration in the Drosophila embryo serves as an excellent model system to study how cell migration is controlled and influences organogenesis. First, mesoderm spreading transforms the embryo into a multilayered form during gastrulation and, subsequently, cells originating from the caudal visceral mesoderm (CVM) migrate along the entire length of the gut. Here we review our studies, which have focused on the role of fibroblast growth factor (FGF) signaling, and compare and contrast these two different cell migration processes: mesoderm spreading and CVM migration. In both cases, FGF acts as a chemoattractant to guide cells' directional movement but is likely not the only signal that serves this role. Furthermore, FGF likely modulates cell adhesion properties since FGF mutant phenotypes share similarities with those of cell adhesion molecules. Our working hypothesis is that levels of FGF signaling differentially influence cells' response to result in either directional movement or changes in adhesive properties.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据