期刊
CELL ADHESION & MIGRATION
卷 6, 期 6, 页码 541-546出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.22408
关键词
semaphorin; VEGF; synapse; plasticity; synaptogenesis; blood vessel
类别
资金
- Wellcome Trust [092839/Z/10/Z, 095623/Z/11/Z]
- BBSRC [BB/I008373/1]
- Wellcome Trust [092839/Z/10/Z] Funding Source: Wellcome Trust
- BBSRC [BB/I008373/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/I008373/1] Funding Source: researchfish
Synapse formation, maintenance and plasticity are critical for the correct function of the nervous system and its target organs. During development, these processes enable the establishment of appropriate neural circuits. During adulthood, they allow adaptation to both physiological and environmental changes. In this review, we discuss emerging roles for two families of classical axon and vascular guidance cues in synaptogenesis and synaptic plasticity, the semaphorins and the vascular endothelial growth factors (VEGFs). Their contribution to synapse formation and function add a new facet to the spectrum of overlapping and complementary roles for these molecules in development, adulthood and disease.
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