期刊
CELL ADHESION & MIGRATION
卷 6, 期 6, 页码 554-560出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.22419
关键词
VEGF; neuropilin; integrin; cancer
类别
资金
- NIH [CA168464]
- DOD Prostate Cancer Grant [PC111410]
- CDMRP [PC111410, 546898] Funding Source: Federal RePORTER
This review advances the hypothesis that the ability of integrins to engage their extracellular matrix ligands and signal can be regulated in tumor cells by vascular endothelial growth factor (VEGF), a major angiogenic factor that also has direct effects on the function of tumor cells. More specifically, we will discuss how neuropilins (NRPs), a distinct class of VEGF receptors, enable the function of specific integrins that contribute to tumor initiation and progression.
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