期刊
CELL ADHESION & MIGRATION
卷 5, 期 2, 页码 150-159出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.5.2.14398
关键词
caldesmon; actin cytoskeleton; cell migration; cell invasion; transcription; smooth muscle contraction; cytokinesis
类别
资金
- Japan Society for the Promotion of Science [20240038, 21700352]
- Grants-in-Aid for Scientific Research [20240038, 21700352] Funding Source: KAKEN
The actin cytoskeleton plays a key role in regulating cell motility. Caldesmon (CaD) is an actin-linked regulatory protein found in smooth muscle and non-muscle cells that is conserved among a variety of vertebrates. It binds and stabilizes actin filaments, as well as regulating actin-myosin interaction in a calcium (Ca2+)/calmodulin (CaM)- and/or phosphorylation-dependent manner. CaD function is regulated qualitatively by Ca2+/CaM and by its phosphorylation state and quantitatively at the mRNA level, by three different transcriptional regulation of the CALD1 gene. CaD has numerous functions in cell motility, such as migration, invasion and proliferation, exerted via the reorganization of the actin cytoskeleton. Here we will outline recent findings regarding CaD's structural features and functions.
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