期刊
CELL ADHESION & MIGRATION
卷 5, 期 5, 页码 387-394出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.5.5.17985
关键词
axon regeneration; C. elegans; genetics; femtosecond laser; neuronal circuits
类别
资金
- Whitehall Foundation
- March of Dimes Foundation
- CIHR [RMF-82501]
Research into conditions that improve axon regeneration has the potential to open a new door for treatment of brain injury caused by stroke and neurodegenerative diseases of aging, such as Alzheimer, by harnessing intrinsic neuronal ability to reorganize itself. Elucidating the molecular mechanisms of axon regeneration should shed light on how this process becomes restricted in the postnatal stage and in the CNS and therefore could provide therapeutic targets for developing strategies to improve axon regeneration in the adult CNS. In this review, we first discuss the general view about nerve regeneration and the advantages of using C. elegans as a model system to study axon regeneration. We then compare the conserved regeneration patterns and molecular mechanisms between C. elegans and vertebrates. Lastly, we discuss the power of femtosecond laser technology and its application in axon regeneration research.
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