期刊
CELL ADHESION & MIGRATION
卷 4, 期 1, 页码 130-145出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.4.1.10882
关键词
lung cancer; semaphorin; neuropilin; slit; robo; ephrin; netrin; DCC; UNC5; notch
类别
资金
- University of Poitiers
- CNRS
- La Ligue Contre le Cancer
- L'Association pour la Recherche sur le Cancer
- National Institutes of Health [CA58187]
- NATIONAL CANCER INSTITUTE [P50CA058187] Funding Source: NIH RePORTER
Guidance molecules were first described in the nervous system to control axon outgrowth direction. They are also widely expressed outside the nervous system where they control cell migration, tissue development and establishment of the vascular network. In addition, they are involved in cancer development, tumor angiogenesis and metastasis. This review is primarily focused on their functions in lung cancer and their involvement in lung development is also presented. Five guidance molecule families and their corresponding receptors are described, including the semaphorins/neuropilins/plexins, ephrins and Eph receptors, netrin/DCC/UNC5, Slit/Robo and Notch/Delta. In addition, the possibility to target these molecules as a therapeutic approach in cancer is discussed.
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