期刊
CELL ADHESION & MIGRATION
卷 4, 期 2, 页码 235-240出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.4.2.11404
关键词
migration; proliferation; multipotent mesenchymal stromal cells; chemokines; demyelination
类别
资金
- The Ipsen Trust
- The Patrick Berthoud Charitable Foundation
- The Burden Trust
- National Institute for Health Research [CL-2010-25-003] Funding Source: researchfish
Systemic delivery of multipotent mesenchymal stem cells (MSC) may be of benefit in the treatment of neurological diseases, including multiple sclerosis (MS). Certainly, animal studies have demonstrated functional benefits following MSC transplantation, although the mechanisms by which MSCs migrate to lesions and stimulate repair remain unknown. Chemokines stimulate migration in other settings. In this study, we systematically explore the migratory and proliferative responses of human MSCs (hMSC) to chemokines expressed in MS lesions. We demonstrate that these chemokines trigger hMSC migration. In addition, we show that RANTES and IP-10 promote hMSC proliferation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据