期刊
CELL ADHESION & MIGRATION
卷 3, 期 1, 页码 19-23出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.3.1.7149
关键词
GRK2; GPCR; GIT1; cell migration; integrins; chemokines
类别
资金
- Ministerio de Educacion y Ciencia [SAF2005-03053]
- Fundacion Mutua Madrilena
- Fundacion Ramon Areces
- The Cardiovascular Network (RECAVA) of Ministerio Sanidad y Consumo-Instituto Carlos III [RD06-0014/0037]
- Comunidad de Madrid [S-SAL-0159-2006]
- MAIN European Network [LSHG-CT-2003-502935]
G protein-coupled receptor kinase 2 (GRK2) was initially identified as a key player, together with beta-arrestins, in the regulation of multiple G protein-coupled receptors (GPCR). Further research has revealed a complex GRK2 interactome, that includes a variety of proteins related to cell motility, and a role for GRK2 kinase activity in inhibiting chemokine-induced immune cell migration. In addition, we have recently reported that GRK2 positively regulates integrin and sphingosine-1-phosphate-dependent motility in epithelial cell types and fibroblasts, acting as a scaffold molecule. We suggest that the positive or negative correlation of GRK2 levels with cell migration would depend on the cell type, specific stimuli acting through plasma membrane receptors, or on the signalling context, leading to differential networks of interaction of GRK2 with cell migration-related signalosomes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据