Designing bifunctional acid-base mesoporous hybrid catalysts for cascade reactions

Bifunctional mesoporous hybrid materials, containing both proton sponges and acid groups, have been prepared following different synthetic routes: co-condensation processes (sol-gel or micellar one-pot routes) or post-synthetic grafting of the organic functionalities. 1,8-Bis(dimethylamino)naphthalene (DMAN), a proton sponge with high pK(a), was used as an organic functional builder base and 3-mercaptopropyltriethoxysilane (MPTES) as a pendant precursor of sulfonic acids. The bifunctional hybrid materials were extensively characterized and were investigated as heterogeneous catalysts for various one-pot C-C bond-forming cascade reactions such as deacetalization-Knoevenagel condensation or deacetalization-nitroaldol (Henry) reaction.