期刊
CATALYSIS SCIENCE & TECHNOLOGY
卷 2, 期 9, 页码 1886-1893出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cy00516f
关键词
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资金
- National Agency of Research [ANR-07-BLAN-0167-01/ 02]
- CNRS
- Agence Nationale de la Recherche (ANR) [ANR-07-BLAN-0167] Funding Source: Agence Nationale de la Recherche (ANR)
A promising route for the double carbonylation of aryl iodide derivatives with secondary and primary amines to produce alpha-ketoamides is described using covalently immobilized palladium complexes on SBA-15 silica. Adequate adjustments of the different reaction parameters (temperature, CO pressure, nature of base, solvent, substrate...) to achieve optimal catalyst performance were made using PdCl2(PPh2)(2)@SBA-15 as catalytic system. High conversions (up to 80%) and excellent selectivities (up to 96%) for the double carbonylated alpha-ketoamide products were obtained using K2CO3 as base, MEK or DMF as solvent and a 1 mol% [Pd] catalyst. We also demonstrated that two other palladium hybrid mesoporous materials can be alternatively used, namelyPdCl(2)(PCy2)(2)@SBA-15 and PdCl2(PNP)@SBA-15, without loss of activity and selectivity. Finally, catalyst recycling of PdCl2(PPh2)(2)@SBA-15 showed that the catalyst could be reused for up to 3 cycles without affecting catalyst performance.
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