期刊
CANCER GENETICS
卷 206, 期 1-2, 页码 19-25出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cancergen.2012.12.002
关键词
CLL; recurrent genomic aberrations; interphase FISH; MLPA
资金
- Ligue Contre le Cancer (Auvergne, France)
To better define the place of multiplex ligation-dependent probe amplification (MLPA) in routine cytogenetic diagnosis in chronic lymphocytic leukemia (CLL), we compared MLPA and fluorescence in situ hybridization (iFISH) data obtained in 77 CLL patients. Although MLPA detected most recurrent copy number genomic aberrations (90.9%), false-negative results were found in cases with small-size abnormal clones and false-positive MLPA findings resulting from point mutations (TP53) or an apparent lack of probe specificity (chromosome 19) were observed. Thus, MLPA may be a useful complementary but not alternative approach for iFISH testing of genomic aberration in CLL.
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