期刊
CANCER DISCOVERY
卷 3, 期 7, 页码 726-727出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2159-8290.CD-13-0244
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In this issue of Cancer Discovery, Dominguez and colleagues identify diacylglycerol kinase alpha (DGK alpha), an enzyme that converts the membrane lipid diacylglycerol to phosphatidic acid, as a central node upstream of mTOR and other oncogenic pathways. Importantly, targeting DGKa causes apoptosis in cancer cells and tumor growth inhibition in mice with no overt toxicity, implicating DGKa as a novel cancer-specific target. (C) 2013 AACR.
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