期刊
CANCER DISCOVERY
卷 2, 期 12, 页码 1078-1080出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2159-8290.CD-12-0465
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- NCI NIH HHS [R01 CA129523, R01 CA057621] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007618] Funding Source: Medline
Mitra and colleagues analyzed microRNA expression profiles of fibroblasts isolated from ovarian cancer patients, searching for dysregulated microRNAs in the stromal compartment of human cancer. They found that decreased miR-31 and miR-214 and increased miR-155 expression can reprogram normal fibroblasts into tumor-promoting cancer-associated fibroblasts. They identified CCL5, a protumorigenic chemokine that is highly expressed in tumors, as a key target of miR-214, thus showing that microRNA perturbation in the stromal microenvironment can affect tumor growth. Cancer Discov; 2(12); 1078-80. (C) 2012 AACR.
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