NF-κB in Cancer: A Matter of Life and Death

Activation of NF-kappa B has been linked to various cellular processes in cancer, including inflammation, transformation, proliferation, angiogenesis, invasion, metastasis, chemoresistance, and radioresistance. Although acute inflammation mediates innate and humoral immunity, chronic inflammation has been linked to tumorigenesis. Thus, inhibition of NF-kappa B has therapeutic potential in sensitization of tumors to chemotherapeutic agents; however, generalized suppression of NF-kappa B can result in serious host toxicity with minimum effect on the tumor. Cancer Discovery; 1(6); 469-71. (C) 2011 AACR.