期刊
CANCER DETECTION AND PREVENTION
卷 32, 期 5-6, 页码 352-362出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.canep.2009.03.001
关键词
Beer; Wine; Spirits; Ethanol; Neoplasms; Population-based; Epidemiology; Observational
类别
资金
- Health Canada,
- National Cancer Institute of Canada
- Institut de recherche en sante et securite au travail du Quebec
- Fonds de la recherche en sante du Quebec
- Canadian Institutes of Health Research
Background: The aim of the study was to investigate the association between lifetime consumption of alcoholic beverages and cancer risk. Methods: Data were collected in a population-based case-control study, conducted in Montreal in the mid-1980s, designed to assess the associations between hundreds of non-occupational and occupational exposures and multiple cancer sites in men. We present results for 13 cancer sites: oesophagus (n = 78), stomach (n = 215), colon (n = 427), rectum (n = 239), liver (n = 28), pancreas (n = 83), lung (n = 700), melanoma (n = 107), prostate (n = 374), bladder (n = 425), kidney (n = 156), Hodgkin's lymphoma (n = 42), and non-Hodgkin's lymphoma (n = 190), in comparison to population controls (n = 507). Odds ratios (OR) were estimated for the associations between lifetime consumption of total alcoholic beverages, beer, wine, and/or spirits, alto-ether and separately, and each cancer site, while carefully adjusting for smoking and other covariates using polytomous logistic regression. Results: For several cancers (oesophagus, stomach, colon, liver, pancreas, lung, prostate) there was evidence of increased risk among alcohol consumers compared with abstainers and occasional drinkers. For most sites, it was beer and to a lesser extent spirits consumption that drove the excess risks. Conclusions: Our results support the hypothesis that moderate and high alcohol intake levels over the lifetime might increase cancer risk at several sites. (C) 2009 Elsevier Ltd. All rights reserved.
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