期刊
BIOMEDICAL OPTICS EXPRESS
卷 9, 期 9, 页码 4413-4428出版社
Optica Publishing Group
DOI: 10.1364/BOE.9.004413
关键词
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资金
- National Key Research and Development Program of China [2016YFF0103000, 2016YFC0208600]
- Science and Technology Project of Shenzhen [JCYJ20170412170814624]
- National Natural Science Foundation of China (NSFC) [61405102, 61527826, 41475125]
Mueller matrix polarimetry is a potentially powerful tool for biomedical diagnosis. Recently, the transmission Mueller matrix microscope and backscattering Mueller matrix endoscope were developed and applied to various pathological samples. However, a comparative study of imaging contrasts of Mueller matrix derived parameters between transmission and backscattering measurements is still needed to help decide which information obtained from transmission Mueller matrix microscope can be directly applied to in vivo Mueller matrix imaging. Here, to compare the imaging contrasts of Mueller matrix derived parameters between transmission and backscattering polarimetry, we measure porcine liver tissue samples and human breast carcinoma tissue specimens. The experiments and corresponding Monte Carlo stimulation results demonstrate that the backscattering and transmission retardance-related Mueller matrix parameters have very similar contrasts to characterize the anisotropic and isotropic structures of pathological tissues, meaning that the conclusions made from Mueller matrix microscopic imaging based on retardance can also be helpful to guide the in situ backscattering Mueller matrix polarimetric diagnosis. However, the values and contrasts of depolarization-related Mueller matrix parameters have some differences between transmission and backscattering polarimetry. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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