期刊
BIOMEDICAL OPTICS EXPRESS
卷 5, 期 2, 页码 547-559出版社
OPTICAL SOC AMER
DOI: 10.1364/BOE.5.000547
关键词
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资金
- CIHR - Canadian Institutes of Health Research
- NSERC - Natural Sciences and Engineering Research Council of Canada
- MSFHR - Michael Smith Foundation for Health Research
- FFB - Foundation Fighting Blindness
- National Eye Institute [EY 014743]
- UC Davis RISE Grant
- NSF I/UCRC CBSS Grant
- Short Term Mobility program of the National Council of Research of Italy
- Research to Prevent Blindness
- Directorate For Engineering
- Div Of Industrial Innovation & Partnersh [1068070] Funding Source: National Science Foundation
We present wavefront sensorless adaptive optics (WSAO) Fourier domain optical coherence tomography (FD-OCT) for in vivo small animal retinal imaging. WSAO is attractive especially for mouse retinal imaging because it simplifies optical design and eliminates the need for wavefront sensing, which is difficult in the small animal eye. GPU accelerated processing of the OCT data permitted real-time extraction of image quality metrics (intensity) for arbitrarily selected retinal layers to be optimized. Modal control of a commercially available segmented deformable mirror (IrisAO Inc.) provided rapid convergence using a sequential search algorithm. Image quality improvements with WSAO OCT are presented for both pigmented and albino mouse retinal data, acquired in vivo. (C) 2014 Optical Society of America
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