期刊
BIOMEDICAL OPTICS EXPRESS
卷 4, 期 10, 页码 1795-1805出版社
OPTICAL SOC AMER
DOI: 10.1364/BOE.4.001795
关键词
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资金
- NSF [CBET-0933059]
- NIH [T32 EB001040]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0933059] Funding Source: National Science Foundation
Structured illumination microscopy (SIM) is an established microscopy technique typically used to image samples at resolutions beyond the diffraction limit. Until now, however, achieving sub-diffraction resolution has predominantly been limited to intensity-based imaging modalities. Here, we introduce an analogue to conventional SIM that allows sub-diffraction resolution, quantitative phase-contrast imaging of optically transparent objects. We demonstrate sub-diffraction resolution amplitude and quantitative-phase imaging of phantom targets and enhanced resolution quantitative-phase imaging of cells. We report a phase accuracy to within 5% and phase noise of 0.06 rad. (C) 2013 Optical Society of America
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