期刊
BIOMEDICAL OPTICS EXPRESS
卷 3, 期 12, 页码 -出版社
OPTICAL SOC AMER
DOI: 10.1364/BOE.3.003240
关键词
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资金
- NSERC [355544-2008, 375340-2009, STPGP 396444]
- Terry-Fox Foundation
- Canadian Cancer Society [TFF 019237, TFF 019240, CCS 2011-700718]
- Alberta Cancer Research Institute [ACB 23728]
- Canada Foundation for Innovation, Leaders Opportunity Fund [18472]
- Alberta Advanced Education & Technology, Small Equipment Grants Program [URSI09007SEG]
- University of Alberta Startup Funds
- China Scholarship Council scholarships for graduate student Peng Shao
Photoacoustic tomography is a promising imaging modality offering high ultrasonic resolution with intrinsic optical contrast. However, quantification in photoacoustic imaging is challenging. We present an algorithm for quantitative photoacoustic estimation of optical absorption and diffusion coefficients based on minimizing an error function between measured photoacoustic channel data and a calculated forward model with a multiple-illumination pattern. Unlike many other algorithms, the proposed method does not require the erroneous assumption of ideal tomographic reconstruction of initial pressures and to our knowledge is the first demonstration of the efficacy of multiple-illumination photoacoustic tomography requiring only transducer channel data. Simulations show promise for numerically robust optical property estimation as illustrated by well-conditioned Hessian singular values in 2D examples. (C) 2012 Optical Society of America
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