期刊
BIOMEDICAL OPTICS EXPRESS
卷 3, 期 10, 页码 2550-2566出版社
OPTICAL SOC AMER
DOI: 10.1364/BOE.3.002550
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资金
- UK Medical Research Council
- Central London Research Network
- Department of Health's National Institute for Health Research Centres funding scheme
- Medical Research Council [G1000292, G0701458] Funding Source: researchfish
- MRC [G0701458, G1000292] Funding Source: UKRI
Using transcranial near-infrared spectroscopy (NIRS) to measure ;changes in the redox state of cerebral cytochrome c oxidase (Delta[oxCCO]) during functional activation in healthy adults is hampered by instrumentation and algorithm issues. This study reports the Delta[oxCCO] response measured in such a setting and investigates possible confounders of this measurement. Continuous frontal lobe NIRS measurements were collected from 11 healthy volunteers during a 6-minute anagram-solving task, using a hybrid optical spectrometer (pHOS) that combines multi-distance frequency and broadband components. Only data sets showing a hemodynamic response consistent with functional activation were interrogated for a Delta[oxCCO] response. Simultaneous systemic monitoring data were also available. Possible influences on the Delta[oxCCO] response were systematically investigated and there was no effect of: 1) wavelength range chosen for fitting the measured attenuation spectra; 2) constant or measured, with the pHOS in real-time, differential pathlength factor; 3) systemic hemodynamic changes during functional activation; 4) changes in optical scattering during functional activation. The Delta[oxCCO] response measured in the presence of functional activation was heterogeneous, with the majority of subjects showing significant increase in oxidation, but others having a decrease. We conclude that the heterogeneity in the Delta[oxCCO] response is physiological and not induced by confounding factors in the measurements. (C) 2012 Optical Society of America
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