期刊
BIOMEDICAL OPTICS EXPRESS
卷 2, 期 6, 页码 1514-1523出版社
OPTICAL SOC AMER
DOI: 10.1364/BOE.2.001514
关键词
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资金
- Breast Cancer Management System
- Nelly B. Connally Breast Cancer Research Fund
Rapid in situ determination of surgical resection margins during breast cancer surgery would reduce patient time under anesthesia. We present preliminary data supporting the use of a fluorescent glucose analog (2-NBDG) as an optical contrast agent to differentiate freshly excised breast tissue containing cancerous cells from normal breast tissue. Multi-spectral images of 14 breast cancer specimens acquired before and after incubation with 2-NBDG demonstrated increased fluorescent signal in all of the malignant tissue due to increased 2-NBDG consumption. We demonstrate that 2-NBDG has potential as an optical contrast agent to differentiate cancerous from non-cancerous tissue. (C)2011 Optical Society of America
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