期刊
BIOMEDICAL OPTICS EXPRESS
卷 1, 期 1, 页码 278-284出版社
OPTICAL SOC AMER
DOI: 10.1364/BOE.1.000278
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资金
- National Institutes of Health (Network for Translational Research) [U54 CA136398, R01 EB008085, R01 EB000712]
Using a hand-held photoacoustic probe integrated with a clinical ultrasound array system, we successfully imaged objects deeply positioned in biological tissues. The optical contrasts were enhanced by methylene blue with a concentration of similar to 30 mM. The penetration depth reached similar to 5.2 cm in chicken breast tissue by using 650-nm wavelength, which is similar to 4.7 times the 1/e optical penetration depth. This imaging depth was achieved using a laser fluence on the tissue surface of only 3 mJ/cm(2), which is 1/7 of the American National Standards Institute (ANSI) safety limit (20 mJ/cm(2)). The noise equivalent sensitivity at this depth was similar to 11 mM. Further, after intradermal injection of methylene blue in a rat, a sentinel lymph node was easily detected in vivo, beneath a 2-cm thick layer of chicken breast. Also, blood located 3.5 cm deep in the rat was clearly imaged with intrinsic contrast. We have photoacoustically guided insertion of a needle into a rat sentinel lymph node with accumulated methylene blue. These results highlight the clinical potential of photoacoustic image-guided identification and needle biopsy of sentinel lymph nodes for axillary staging in breast cancer patients. (C) 2010 Optical Society of America
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