期刊
BIOMEDICAL OPTICS EXPRESS
卷 1, 期 1, 页码 201-208出版社
OPTICAL SOC AMER
DOI: 10.1364/BOE.1.000201
关键词
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资金
- Engineering and Physical Sciences Research Council, UK
- EPSRC [EP/E050980/1, EP/H005536/1] Funding Source: UKRI
In biomedical photoacoustic imaging the images are proportional to the absorbed optical energy density, and not the optical absorption, which makes it difficult to obtain a quantitatively accurate image showing the concentration of a particular absorbing chromophore from photoacoustic measurements alone. Here it is shown that the spatially varying concentration of a chromophore whose absorption becomes zero above a threshold light fluence can be estimated from photoacoustic images obtained at increasing illumination strengths. This technique provides an alternative to model-based multiwavelength approaches to quantitative photoacoustic imaging, and a new approach to photoacoustic molecular and functional imaging. (C) 2010 Optical Society of America
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