期刊
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
卷 5, 期 -, 页码 1312-1319出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjnano.5.144
关键词
camptothecin; cancer therapy; iron oxide superparamagnetic nanoparticles; polyethylene glycol
资金
- Fundacion Progreso y Salud, Consejeria de Salud [PI0070]
- Proyecto de Investigacion de Excelencia de la Junta de Andalucia [P10-FQM-6615]
Camptothecin (CPT; (S)-(+)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione) is a highly cytotoxic natural alkaloid that has not yet found use as chemotherapeutic agent due to its poor water-solubility and chemical instability and, as a consequence, no effective administration means have been designed. In this work, camptothecin has been successfully loaded into iron oxide superparamagnetic nanoparticles with an average size of 14 nm. It was found that surface modification of the nanoparticles by polyethylene glycol enables loading a large amount of camptothecin. While the unloaded nanoparticles do not induce apoptosis in the H460 lung cancer cell line, the camptothecin-loaded nanoparticle formulations exhibit remarkable proapoptotic activity. These results indicate that camptothecin retains its biological activity after loading onto the magnetic nanoparticles. The proposed materials represent novel materials based on naturally occurring bioactive molecules loaded onto nanoparticles to be used as chemotherapeutic formulations. The procedure seems apt to be extended to other active molecules extracted from natural products. In addition, these materials offer the potential of being further implemented for combined imaging and therapeutics, as magnetic nanoparticles are known to be multifunctional tools for biomedicine.
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