期刊
ARABIAN JOURNAL OF CHEMISTRY
卷 7, 期 5, 页码 623-629出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.arabjc.2013.11.036
关键词
Multi-component reactions (MCR); Microwave irradiation; Enaminone; 1-Benzothiopyran-4-one; Antitumor activity
The multi-component reaction of 1-benzothiopyran-4-ones with heterocyclic amines and dimethylformamide-dimethylacetal (DMFDMA) in DMF at 150 degrees C under controlled microwave heating afforded novel poly-heterocyclic ring systems. Also, reaction of 3-dimethylaminomethylene-1-benzothiopyran-4-one with activemethylene derivatives was investigated. The structure of all products was established on the bases of spectral data and elemental analyses and alternative synthesis if possible. The prepared compounds were screened for their antitumor activity against HCT-116 colon cancer cell line and some derivatives showed promising activity. (C) 2013 King Saud University. Production and hosting by Elsevier B. V. All rights reserved.
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