期刊
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
卷 6, 期 4, 页码 288-295出版社
KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY
DOI: 10.4168/aair.2014.6.4.288
关键词
Leukotrienes; 5-lipoxygenase; asthma; AERD
资金
- NIH [AI078908, AI095219, AT002782, AI082369, HL111113, HL117945, HL36110]
- Vinik Family
Cysteinyl leukotrienes (cys-LTs) are potent mediators of inflammation derived from arachidonic acid through the 5-lipoxygenase/leukotriene C-4 synthase pathway. The derivation of their chemical structures and identification of their pharmacologic properties predated the cloning of their classical receptors and the development of drugs that modify their synthesis and actions. Recent studies have revealed unanticipated insights into the regulation of cys-LT synthesis, the function of the cys-LTs in innate and adaptive immunity and human disease, and the identification of a new receptor for the cys-LTs. This review highlights these studies and summarizes their potential pathobiologic and therapeutic implications.
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