期刊
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
卷 2, 期 3, 页码 183-187出版社
KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY
DOI: 10.4168/aair.2010.2.3.183
关键词
Oxidative stress; asthma; protein tyrosine phosphatases; antioxidants; immune tolerance; airway inflammation; allergy
资金
- Ministry of Health, Welfare and Family Affairs [A040153]
- Ministry of Education, Science and Technology, Republic of Korea
Oxidative stress plays a critical role in the pathogenesis of asthma. To effectively control oxidative stress in asthmatics, it is important to investigate the precise intracellular mechanism by which the development of immunity, rather than immune tolerance and progression of airway inflammation, is induced. In this article, we suggest that protein tyrosine phosphatases, as intracellular negative regulators, and intracellular antioxidant enzymes such as peroxiredoxins can be regulated by oxidative stress during intracellular signaling.
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